F2R Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | P25116 |
Other Accession | NP_001983.2 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 47441 Da |
Antigen Region | 35-63 aa |
Gene ID | 2149 |
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Other Names | Proteinase-activated receptor 1, PAR-1, Coagulation factor II receptor, Thrombin receptor, F2R, CF2R, PAR1, TR |
Target/Specificity | This F2R antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 35-63 amino acids from the N-terminal region of human F2R. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | F2R Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | F2R |
---|---|
Synonyms | CF2R, PAR1, TR |
Function | High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development. |
Cellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Location | Platelets and vascular endothelial cells. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. [provided by RefSeq].
References
Bae, J.S., et al. J. Biol. Chem. 285(45):34803-34812(2010)
Motovska, Z., et al. Atherosclerosis 212(2):548-552(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Burch, M.L., et al. J. Biol. Chem. 285(35):26798-26805(2010)
Gigante, B., et al. PLoS ONE 5 (6), E11300 (2010) :
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