|Application ||WB, E|
|Calculated MW||47441 Da|
|Antigen Region||35-63 aa|
|Other Names||Proteinase-activated receptor 1, PAR-1, Coagulation factor II receptor, Thrombin receptor, F2R, CF2R, PAR1, TR|
|Target/Specificity||This F2R antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 35-63 amino acids from the N-terminal region of human F2R.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||F2R Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CF2R, PAR1, TR|
|Function||High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Platelets and vascular endothelial cells.|
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Provided below are standard protocols that you may find useful for product applications.
Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. [provided by RefSeq].
Bae, J.S., et al. J. Biol. Chem. 285(45):34803-34812(2010)
Motovska, Z., et al. Atherosclerosis 212(2):548-552(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Burch, M.L., et al. J. Biol. Chem. 285(35):26798-26805(2010)
Gigante, B., et al. PLoS ONE 5 (6), E11300 (2010) :
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