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F2R Antibody (N-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - F2R Antibody (N-term) AP18006A
    F2R Antibody (N-term) (Cat. #AP18006a) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the F2R antibody detected the F2R protein (arrow).
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P25116
Other Accession NP_001983.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 47441 Da
Antigen Region 35-63 aa
Additional Information
Gene ID 2149
Other Names Proteinase-activated receptor 1, PAR-1, Coagulation factor II receptor, Thrombin receptor, F2R, CF2R, PAR1, TR
Target/Specificity This F2R antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 35-63 amino acids from the N-terminal region of human F2R.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsF2R Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name F2R
Synonyms CF2R, PAR1, TR
Function High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.
Cellular Location Cell membrane; Multi-pass membrane protein.
Tissue Location Platelets and vascular endothelial cells.
Research Areas
Citations (0)
citation

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Background

Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. [provided by RefSeq].

References

Bae, J.S., et al. J. Biol. Chem. 285(45):34803-34812(2010)
Motovska, Z., et al. Atherosclerosis 212(2):548-552(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Burch, M.L., et al. J. Biol. Chem. 285(35):26798-26805(2010)
Gigante, B., et al. PLoS ONE 5 (6), E11300 (2010) :

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$ 182.50
$ 70.00
Cat# AP18006A
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