|Application ||WB, E|
|Other Accession||F1P065, NP_005757.1|
|Calculated MW||118633 Da|
|Antigen Region||62-90 aa|
|Other Names||FERM, RhoGEF and pleckstrin domain-containing protein 1, Chondrocyte-derived ezrin-like protein, Pleckstrin homology domain-containing family C member 2, PH domain-containing family C member 2, FARP1, CDEP, PLEKHC2|
|Target/Specificity||This FARP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 62-90 amino acids from the N-terminal region of human FARP1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FARP1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Functions as guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity).|
|Cellular Location||Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse. Cell junction, synapse, synaptosome. Cytoplasm, cytosol. Cell projection, filopodium. Cell projection, dendrite. Cell projection, dendritic spine Note=Recruited to the cell membrane via interaction with CADM1|
|Tissue Location||Detected in cAMP-treated chondrocytes, but not in untreated chondrocytes. Detected in fetal brain, heart and spleen, and in adult testis, kidney and lung|
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Provided below are standard protocols that you may find useful for product applications.
This gene was originally isolated through subtractive hybridization due to its increased expression in differentiated chondrocytes versus dedifferentiated chondrocytes. The resulting protein contains a predicted ezrin-like domain, a Dbl homology domain, and a pleckstrin homology domain. It is believed to be a member of the band 4.1 superfamily whose members link the cytoskeleton to the cell membrane. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Stein, J.L., et al. Neuroimage 53(3):1160-1174(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Evangelou, E., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (1), 220-228 (2010) :
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
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