|Application ||WB, E|
|Calculated MW||24123 Da|
|Antigen Region||108-137 aa|
|Other Names||Factor in the germline alpha, FIGalpha, Class C basic helix-loop-helix protein 8, bHLHc8, Folliculogenesis-specific basic helix-loop-helix protein, Transcription factor FIGa, FIGLA, BHLHC8|
|Target/Specificity||This FIGLA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 108-137 amino acids from the Central region of human FIGLA.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FIGLA Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E- box (5'-CANNTG-3') of the ZPs (ZP1, ZP2, ZP3) promoters.|
|Tissue Location||Germ cells. Expressed in the fetal ovary, but not by a range of other tissues. Expression increases across mid- gestation, rising some 40-fold by the time of primordial follicle formation.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein that functions in postnatal oocyte-specific gene expression. The protein is a basic helix-loop-helix transcription factor that regulates multiple oocyte-specific genes, including genes involved in folliculogenesis and those that encode the zona pellucida. Mutations in this gene cause premature ovarian failure type 6.
van Dooren, M.F., et al. Curr. Opin. Obstet. Gynecol. 21(4):313-317(2009)
Fowler, P.A., et al. J. Clin. Endocrinol. Metab. 94(4):1427-1435(2009)
Tormala, R.M., et al. Mol. Cell. Endocrinol. 289 (1-2), 10-15 (2008) :
Zhao, H., et al. Am. J. Hum. Genet. 82(6):1342-1348(2008)
Suzumori, N., et al. Curr. Med. Chem. 14(3):353-357(2007)
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