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FZD7 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - FZD7 Antibody (Center) AP18021c
    FZD7 Antibody (Center) (Cat. #AP18021c) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the FZD7 antibody detected the FZD7 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O75084
Other Accession Q61090, O57329, NP_003498.1
Reactivity Human
Predicted Chicken, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 63620 Da
Antigen Region 202-229 aa
Additional Information
Gene ID 8324
Other Names Frizzled-7, Fz-7, hFz7, FzE3, FZD7
Target/Specificity This FZD7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 202-229 amino acids from the Central region of human FZD7.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFZD7 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FZD7
Function Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
Cellular Location Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein
Tissue Location High expression in adult skeletal muscle and fetal kidney, followed by fetal lung, adult heart, brain, and placenta. Specifically expressed in squamous cell esophageal carcinomas
Research Areas
Citations (0)

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Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.


Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010)
Vincan, E., et al. Dev. Dyn. 239(1):311-317(2010)
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Hosgood, H.D. III, et al. Respir Med 103(12):1866-1870(2009)
Ueno, K., et al. Br. J. Cancer 101(8):1374-1381(2009)

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$ 295.00
$ 99.00
Cat# AP18021c
(40 western blots)
Availability: In Stock
Bulk Size
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