GLIPR1L1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q6UWM5 |
Other Accession | NP_689992.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 27151 Da |
Antigen Region | 196-224 aa |
Gene ID | 256710 |
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Other Names | GLIPR1-like protein 1, GLIPR1L1 |
Target/Specificity | This GLIPR1L1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 196-224 amino acids from the C-terminal region of human GLIPR1L1. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | GLIPR1L1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | GLIPR1L1 |
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Function | Required for optimal fertilization at the stage of sperm- oocyte fusion, plays a role in optimizing acrosome function, the translocation of IZUMO1 during the acrosome reaction and the fertilization process. Component of epididymosomes, one type of membranous microvesicules which mediate the transfer of lipids and proteins to spermatozoa plasma membrane during epididymal maturation. Also component of the CD9-positive microvesicules found in the cauda region. |
Cellular Location | Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q9DAG6}. Cell membrane {ECO:0000250|UniProtKB:Q9DAG6}; Lipid-anchor, GPI-anchor; Extracellular side {ECO:0000250|UniProtKB:Q9DAG6}. Membrane raft {ECO:0000250|UniProtKB:Q32LB5}. Secreted {ECO:0000250|UniProtKB:Q9DAG6}. Note=Located in the connecting piece of elongated spermatids and sperm. Also located in the apical region of the sperm head after sperm capacitation (By similarity). Weakly attached to the cell membrane and later secreted into the extracellular space (By similarity). Located on sperm equatorial segment and neck (By similarity). Associated with epididymosomes from the caput and cauda epididymis (By similarity). {ECO:0000250|UniProtKB:Q32LB5, ECO:0000250|UniProtKB:Q9DAG6} |
Tissue Location | Highly expressed in testis. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The function of this protein remains unknown.
References
Ren, C., et al. Genomics 88(2):163-172(2006)
Zhang, Z., et al. Protein Sci. 13(10):2819-2824(2004)
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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