|Application ||WB, E|
|Calculated MW||57904 Da|
|Antigen Region||15-44 aa|
|Other Names||Alanine aminotransferase 2, ALT2, Glutamate pyruvate transaminase 2, GPT 2, Glutamic--alanine transaminase 2, Glutamic--pyruvic transaminase 2, GPT2, AAT2, ALT2|
|Target/Specificity||This GPT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15-44 amino acids from the N-terminal region of human GPT2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GPT2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate.|
|Tissue Location||Expressed at high levels in muscle, adipose tissue, kidney and brain and at lower levels in the liver and breast.|
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Provided below are standard protocols that you may find useful for product applications.
GPT (MIM 138200) and GPT2 (EC 22.214.171.124), also known as alanine transaminases, are pyridoxal enzymes that catalyze the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. By mediating the conversion of these 4 major intermediate metabolites, these transaminases have roles in gluconeogenesis and in amino acid metabolism.
Glinghammar, B., et al. Int. J. Mol. Med. 23(5):621-631(2009)
Fraser, A., et al. Hepatology 46(1):158-165(2007)
Ding, Y., et al. World J. Gastroenterol. 12(43):7038-7041(2006)
Martin, J., et al. Nature 432(7020):988-994(2004)
Yang, R.Z., et al. Genomics 79(3):445-450(2002)
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