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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   FCHO2 Antibody (Center)   

FCHO2 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - FCHO2 Antibody (Center) AP18034c
    FCHO2 Antibody (Center) (Cat. #AP18034c) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the FCHO2 antibody detected the FCHO2 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q0JRZ9
Other Accession Q3UQN2, NP_620137.2
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 88924 Da
Antigen Region 137-165 aa
Additional Information
Gene ID 115548
Other Names FCH domain only protein 2, FCHO2
Target/Specificity This FCHO2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 137-165 amino acids from the Central region of human FCHO2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFCHO2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FCHO2
Function Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP- 2-dependent endocytosis of the transferin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor.
Cellular Location Membrane, clathrin-coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Associated with forming but not mature clathrin-coated vesicles. The recruitment to coated-pits precede the one of clathrin and the adaptor protein complex AP-2 (By similarity).
Research Areas
Citations (0)

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FCHO2 may play a role in membrane remodeling by imposing and stabilizing particular membrane curvatures.


Henne, W.M., et al. Structure 15(7):839-852(2007)
Katoh, M., et al. Int. J. Mol. Med. 14(2):327-331(2004)

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$ 295.00
$ 99.00
Cat# AP18034c
(40 western blots)
Availability: In Stock
Bulk Size
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