|Application ||WB, E|
|Calculated MW||97726 Da|
|Antigen Region||360-388 aa|
|Other Names||Fanconi anemia group B protein, Protein FACB, Fanconi anemia-associated polypeptide of 95 kDa, FAAP95, FANCB|
|Target/Specificity||This FANCB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 360-388 amino acids from the Central region of human FANCB.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FANCB Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||DNA repair protein required for FANCD2 ubiquitination.|
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Provided below are standard protocols that you may find useful for product applications.
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group B. Alternative splicing results in two transcript variants encoding the same protein.
Cheung, K.L., et al. World J Surg Oncol 8, 38 (2010) :
Smith, I.M., et al. ORL J. Otorhinolaryngol. Relat. Spec. 72(1):44-50(2010)
Barroso, E., et al. Breast Cancer Res. Treat. 118(3):655-660(2009)
Garcia, M.J., et al. Breast Cancer Res. Treat. 113(3):545-551(2009)
Nomura, Y., et al. Genes Cells 12(10):1111-1122(2007)
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