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NGFRAP1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q00994 |
| Other Accession | NP_996800.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 12959 Da |
| Antigen Region | 14-42 aa |
| Gene ID | 27018 |
|---|---|
| Other Names | Protein BEX3, Brain-expressed X-linked protein 3, Nerve growth factor receptor-associated protein 1, Ovarian granulosa cell 130 kDa protein HGR74, p75NTR-associated cell death executor, NGFRAP1, BEX3, DXS6984E, NADE |
| Target/Specificity | This NGFRAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 14-42 amino acids from the N-terminal region of human NGFRAP1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | NGFRAP1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | BEX3 (HGNC:13388) |
|---|---|
| Synonyms | DXS6984E, NADE, NGFRAP1 |
| Function | May be a signaling adapter molecule involved in NGFR/p75NTR- mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death. In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates. |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q9WTZ9}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9WTZ9}. Note=Shuttles between the cytoplasm and the nucleus. Associates with replicating mitochondria. {ECO:0000250|UniProtKB:Q9WTZ9} |
| Tissue Location | Found in ovarian granulosa cells, testis, prostate and seminal vesicle tissue. High levels also detected in liver |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
NGFRAP1 may be a signaling adapter molecule involved in p75NTR-mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death (By similarity). May play an important role in the pathogenesis of neurogenetic diseases.
References
Yasui, S., et al. Mol. Cell. Neurosci. 35(1):100-108(2007)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Yu, Y., et al. Brain Res. 1100(1):13-20(2006)
Alvarez, E., et al. Gene 357(1):18-28(2005)
Ross, M.T., et al. Nature 434(7031):325-337(2005)
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