|Application ||WB, E|
|Calculated MW||12959 Da|
|Antigen Region||14-42 aa|
|Other Names||Protein BEX3, Brain-expressed X-linked protein 3, Nerve growth factor receptor-associated protein 1, Ovarian granulosa cell 130 kDa protein HGR74, p75NTR-associated cell death executor, NGFRAP1, BEX3, DXS6984E, NADE|
|Target/Specificity||This NGFRAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 14-42 amino acids from the N-terminal region of human NGFRAP1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NGFRAP1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be a signaling adapter molecule involved in p75NTR- mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death (By similarity). May play an important role in the pathogenesis of neurogenetic diseases.|
|Cellular Location||Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm and the nucleus. Associates with replicating mitochondria (By similarity).|
|Tissue Location||Found in ovarian granulosa cells, testis, prostate and seminal vesicle tissue. High levels also detected in liver.|
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Provided below are standard protocols that you may find useful for product applications.
NGFRAP1 may be a signaling adapter molecule involved in p75NTR-mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death (By similarity). May play an important role in the pathogenesis of neurogenetic diseases.
Yasui, S., et al. Mol. Cell. Neurosci. 35(1):100-108(2007)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Yu, Y., et al. Brain Res. 1100(1):13-20(2006)
Alvarez, E., et al. Gene 357(1):18-28(2005)
Ross, M.T., et al. Nature 434(7031):325-337(2005)
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