|Application ||WB, E|
|Other Accession||Q29513, Q29555, NP_061833.1|
|Calculated MW||32742 Da|
|Antigen Region||78-106 aa|
|Other Names||Glycine N-methyltransferase, GNMT|
|Target/Specificity||This GNMT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 78-106 amino acids from the Central region of human GNMT.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GNMT Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine.|
|Tissue Location||Abundant in liver.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is an enzyme that catalyzes the conversion of S-adenosyl-L-methionine (along with glycine) to S-adenosyl-L-homocysteine and sarcosine. The encoded protein is found in the cytoplasm and acts as a homotetramer. Defects in this gene are a cause of GNMT deficiency (hypermethioninemia).
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Lee, C.M., et al. Gene 443 (1-2), 151-157 (2009) :
Boyles, A.L., et al. Genet. Epidemiol. 33(3):247-255(2009)
Yen, C.H., et al. Toxicol. Appl. Pharmacol. 235(3):296-304(2009)
Franke, B., et al. Birth Defects Res. Part A Clin. Mol. Teratol. 85(3):216-226(2009)
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