|Application ||WB, E|
|Calculated MW||22933 Da|
|Antigen Region||97-123 aa|
|Other Names||Membrane-spanning 4-domains subfamily A member 3, CD20 antigen-like protein, Hematopoietic-specific transmembrane protein 4, HTm4, MS4A3, CD20L, HTM4|
|Target/Specificity||This MS4A3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 97-123 amino acids from the Central region of human MS4A3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MS4A3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Hematopoietic modulator for the G1-S cell cycle transition. Modulates the level of phosphorylation of cyclin- dependent kinase 2 (CDK2) through its direct binding to cyclin- dependent kinase inhibitor 3 (CDKN3/KAP).|
|Cellular Location||Endomembrane system; Multi- pass membrane protein. Cytoplasm, perinuclear region. Note=Located in the perinuclear area|
|Tissue Location||Expressed specifically in hematopoietic cells and tissues|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the membrane-spanning 4A gene family. Members of this protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member likely plays a role in signal transduction and may function as a subunit associated with receptor complexes. The gene encoding this protein is localized to 11q12, among a cluster of related family members. Alternative splicing may result in multiple transcript variants; however, not all variants have been fully described.
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Chinami, M., et al. J. Biol. Chem. 280(17):17235-17242(2005)
Donato, J.L., et al. J. Clin. Invest. 109(1):51-58(2002)
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