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SASS6 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - SASS6 Antibody (Center) AP18074c
    SASS6 Antibody (Center) (Cat. #AP18074c) western blot analysis in Ramos cell line lysates (35ug/lane).This demonstrates the SASS6 antibody detected the SASS6 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q6UVJ0
Other Accession Q80UK7, NP_919268.1
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 74397 Da
Antigen Region 325-352 aa
Additional Information
Gene ID 163786
Other Names Spindle assembly abnormal protein 6 homolog, HsSAS-6, SASS6, SAS6
Target/Specificity This SASS6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 325-352 amino acids from the Central region of human SASS6.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSASS6 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SASS6
Synonyms SAS6
Function Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication: required both for mother-centriole-dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells. Overexpression results in excess foci-bearing centriolar markers.
Cellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Note=Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles (By similarity). Component of the centrosome. Associated only transiently with nascent procentrioles during centriole biogenesis.
Research Areas
Citations (0)

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SAS6 is necessary for centrosome duplication and functions during procentriole formation; SAS6 functions to ensure that each centriole seeds the formation of a single procentriole per cell cycle Strnad et al., (2007) [PubMed 17681132].


Tang, C.J., et al. Nat. Cell Biol. 11(7):825-831(2009)
Strnad, P., et al. Dev. Cell 13(2):203-213(2007)
Kleylein-Sohn, J., et al. Dev. Cell 13(2):190-202(2007)
Habedanck, R., et al. Nat. Cell Biol. 7(11):1140-1146(2005)
Leidel, S., et al. Nat. Cell Biol. 7(2):115-125(2005)

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$ 295.00
$ 99.00
Cat# AP18074c
(40 western blots)
Availability: In Stock
Bulk Size
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