|Application ||WB, E|
|Other Accession||Q80UK7, NP_919268.1|
|Calculated MW||74397 Da|
|Antigen Region||325-352 aa|
|Other Names||Spindle assembly abnormal protein 6 homolog, HsSAS-6, SASS6, SAS6|
|Target/Specificity||This SASS6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 325-352 amino acids from the Central region of human SASS6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SASS6 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication: required both for mother-centriole-dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells. Overexpression results in excess foci-bearing centriolar markers.|
|Cellular Location||Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Note=Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles (By similarity). Component of the centrosome. Associated only transiently with nascent procentrioles during centriole biogenesis.|
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Provided below are standard protocols that you may find useful for product applications.
SAS6 is necessary for centrosome duplication and functions during procentriole formation; SAS6 functions to ensure that each centriole seeds the formation of a single procentriole per cell cycle Strnad et al., (2007) [PubMed 17681132].
Tang, C.J., et al. Nat. Cell Biol. 11(7):825-831(2009)
Strnad, P., et al. Dev. Cell 13(2):203-213(2007)
Kleylein-Sohn, J., et al. Dev. Cell 13(2):190-202(2007)
Habedanck, R., et al. Nat. Cell Biol. 7(11):1140-1146(2005)
Leidel, S., et al. Nat. Cell Biol. 7(2):115-125(2005)
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