HAPLN4 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q86UW8 |
Other Accession | NP_075378.1 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 42801 Da |
Antigen Region | 331-357 aa |
Gene ID | 404037 |
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Other Names | Hyaluronan and proteoglycan link protein 4, Brain link protein 2, HAPLN4, BRAL2, KIAA1926 |
Target/Specificity | This HAPLN4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 331-357 amino acids from the C-terminal region of human HAPLN4. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | HAPLN4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | HAPLN4 |
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Synonyms | BRAL2, KIAA1926 |
Function | Essential for the proper localization of brevican (BCAN), mainly as a perineuronal nets (PNNs)-type deposition in the brainstem and cerebellum thereby playing a key role in the formation and structural organization of PNNs (By similarity). Contributes to the formation and transmission of inhibitory GABAergic synapses between Purkinje cells and deep cerebellar nuclei neurons (By similarity). |
Cellular Location | Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:Q9ESM3} |
Tissue Location | Expressed predominantly in brain. |
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Provided below are standard protocols that you may find useful for product applications.
Background
HAPLN4 binds to hyaluronic acid and may be involved in formation of the extracellular matrix (By similarity).
References
Sim, H., et al. J. Biol. Chem. 284(39):26547-26556(2009)
Bekku, Y., et al. Mol. Cell. Neurosci. 24(1):148-159(2003)
Spicer, A.P., et al. J. Biol. Chem. 278(23):21083-21091(2003)
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