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DNAJC30 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q96LL9 |
| Other Accession | NP_115693.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 25961 Da |
| Antigen Region | 176-202 aa |
| Gene ID | 84277 |
|---|---|
| Other Names | DnaJ homolog subfamily C member 30, Williams-Beuren syndrome chromosomal region 18 protein, DNAJC30, WBSCR18 |
| Target/Specificity | This DNAJC30 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 176-202 amino acids from the C-terminal region of human DNAJC30. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | DNAJC30 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DNAJC30 {ECO:0000303|PubMed:30318146, ECO:0000312|HGNC:HGNC:16410} |
|---|---|
| Function | Mitochondrial protein enriched in neurons that acts as a regulator of mitochondrial respiration (By similarity). Associates with the ATP synthase complex and facilitates ATP synthesis (By similarity). May be a chaperone protein involved in the turnover of the subunits of mitochondrial complex I N-module. It facilitates the degradation of N- module subunits damaged by oxidative stress, and contributes to complex I functional efficiency (PubMed:33465056). |
| Cellular Location | Mitochondrion inner membrane; Single-pass membrane protein |
| Tissue Location | Expressed in brain, heart, kidney, liver, lung, spleen, stomach and testis (PubMed:12073013). Highly expressed in the brain (PubMed:30318146). In the neocortex, expressed in most, if not all, glutamatergic excitatory projection neurons (pyramidal) and many interneurons, with the strongest signal noticeably in large pyramidal neurons of layer 3C. Also present in pyramidal neurons of layer 3C PNs of the superior temporal cortex, as well as in pyramidal neurons (Betz cells) of the layer 5B primary motor cortex (at protein level) (PubMed:30318146). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This intronless gene encodes a member of the DNAJ molecular chaperone homology domain-containing protein family. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23.
References
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Lehner, B., et al. Genome Res. 14(7):1315-1323(2004)
Merla, G., et al. Hum. Genet. 110(5):429-438(2002)
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