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MRGBP Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - MRGBP Antibody (Center) AP18098c
    MRGBP Antibody (Center) (Cat. #AP18098c) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the MRGBP antibody detected the MRGBP protein (arrow).
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9NV56
Other Accession Q9DAT2, NP_060740.1
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 22417 Da
Antigen Region 46-75 aa
Additional Information
Gene ID 55257
Other Names MRG/MORF4L-binding protein, MRG-binding protein, Up-regulated in colon cancer 4, Urcc4, MRGBP, C20orf20
Target/Specificity This MRGBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46-75 amino acids from the Central region of human MRGBP.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMRGBP Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MRGBP
Synonyms C20orf20
Function Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.
Cellular Location Nucleus.
Citations (0)

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Background

Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome -DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.

References

Yamaguchi, K., et al. Br. J. Cancer 102(2):325-331(2010)
Cai, Y., et al. J. Biol. Chem. 280(14):13665-13670(2005)
Cai, Y., et al. J. Biol. Chem. 278(44):42733-42736(2003)
Deloukas, P., et al. Nature 414(6866):865-871(2001)

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$ 295.00
$ 99.00
Cat# AP18098c
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
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