|Application ||FC, WB, E|
|Calculated MW||22900 Da|
|Antigen Region||1-30 aa|
|Other Names||HemK methyltransferase family member 2, 211-, MHsaHemK2P, N(6)-adenine-specific DNA methyltransferase 1, N6AMT1, C21orf127, HEMK2|
|Target/Specificity||This N6AMT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human N6AMT1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||N6AMT1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Heterodimeric methyltransferase that catalyzes N5- methylation of ETF1 on 'Gln-185', using S-adenosyl L-methionine as methyl donor. ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated. May play a role in the modulation of arsenic-induced toxicity. May be involved in the conversion of monomethylarsonous acid (3+) into the less toxic dimethylarsonic acid.|
|Tissue Location||Widely expressed, with highest expression in parathyroid and pituitary glands, followed by adrenal gland and kidney, and lowest expression in leukocytes and mammary gland|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene belongs to the methyltransferase superfamily. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Figaro, S., et al. FEBS Lett. 582(16):2352-2356(2008)
Seshadri, S., et al. BMC Med. Genet. 8 SUPPL 1, S15 (2007) :
Hwang, S.J., et al. BMC Med. Genet. 8 SUPPL 1, S10 (2007) :
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