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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   ARSA Antibody (C-term)   

ARSA Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - ARSA Antibody (C-term) AP18128B
    ARSA Antibody (C-term) (Cat. #AP18128b) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the ARSA antibody detected the ARSA protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O43681
Other Accession O54984, A5PJI5, NP_004308.2
Reactivity Human
Predicted Bovine, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 38793 Da
Antigen Region 284-312 aa
Additional Information
Gene ID 439
Other Names ATPase ASNA1 {ECO:0000255|HAMAP-Rule:MF_03112}, 36-- {ECO:0000255|HAMAP-Rule:MF_03112}, Arsenical pump-driving ATPase {ECO:0000255|HAMAP-Rule:MF_03112}, Arsenite-stimulated ATPase {ECO:0000255|HAMAP-Rule:MF_03112}, Transmembrane domain recognition complex 40 kDa ATPase subunit, hARSA-I, hASNA-I, ASNA1 {ECO:0000255|HAMAP-Rule:MF_03112}, ARSA, TRC40
Target/Specificity This ARSA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 284-312 amino acids from the C-terminal region of human ARSA.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsARSA Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ASNA1 {ECO:0000255|HAMAP-Rule:MF_03112}
Synonyms ARSA, TRC40
Function ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail- anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting (By similarity). May be involved in insulin signaling.
Cellular Location Cytoplasm. Endoplasmic reticulum. Nucleus, nucleolus
Tissue Location Expressed in the epithelial cells of the liver, kidney, and stomach wall, in the adrenal medulla, in the islet cells of the pancreas, in the red pulp of the spleen, and in cardiac and skeletal muscle.
Research Areas
Citations (0)

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ASNA1 is the human homolog of the bacterial arsA gene. In E. coli, ArsA ATPase is the catalytic component of a multisubunit oxyanion pump that is responsible for resistance to arsenicals and antimonials.


Favaloro, V., et al. J. Cell. Sci. 123 (PT 9), 1522-1530 (2010) :
Hemmingsson, O., et al. Oncol. Rep. 22(4):869-875(2009)
Rabu, C., et al. J. Biol. Chem. 283(41):27504-27513(2008)
Stefanovic, S., et al. Cell 128(6):1147-1159(2007)
Kao, G., et al. Cell 128(3):577-587(2007)

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$ 295.00
$ 99.00
Cat# AP18128B
(40 western blots)
Availability: In Stock
Bulk Size
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