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KLF15 Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - KLF15 Antibody (C-term) AP18136b
    KLF15 Antibody (C-term) (Cat. #AP18136b) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the KLF15 antibody detected the KLF15 protein (arrow).
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9UIH9
Other Accession Q9EPW2, NP_054798.1
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 43992 Da
Antigen Region 372-398 aa
Additional Information
Gene ID 28999
Other Names Krueppel-like factor 15, Kidney-enriched krueppel-like factor, KLF15, KKLF
Target/Specificity This KLF15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 372-398 amino acids from the C-terminal region of human KLF15.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsKLF15 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KLF15
Synonyms KKLF
Function Transcriptional regulator that binds to the GA element of the CLCNKA promoter. Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart (By similarity). Is a repressor of CCN2 expression, involved in the control of cardiac fibrosis. It is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A and GATA4 (By similarity). Involved in podocyte differentiation (By similarity). Inhibits MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation.
Cellular Location Nucleus
Tissue Location Highly expressed in liver, skeletal muscle, and kidney. Expressed in cardiomyocytes. Expression is highly reduced in cardiac tissue of patients with non-ischemic cardiomyopathy and aortic aneurysm, and in glomerular disease. Not expressed in bone marrow or lymphoid tissues.
Research Areas
Citations (0)
citation

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Background

KLF15 is a transcriptional activator. Binds to the GA element of the CLCNKA promoter.

References

Yamamoto, K., et al. Biochem. Biophys. Res. Commun. 400(1):175-180(2010)
Haldar, S.M., et al. Sci Transl Med 2 (26), 26RA26 (2010) :
Li, J., et al. BMC Genet. 11, 12 (2010) :
Du, X., et al. J. Clin. Endocrinol. Metab. 94(7):2594-2601(2009)
Wang, B., et al. J. Mol. Cell. Cardiol. 45(2):193-197(2008)

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$ 182.50
$ 70.00
Cat# AP18136b
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