|Application ||WB, E|
|Other Accession||A2VCX1, Q8BH58, NP_001026970.1|
|Calculated MW||31444 Da|
|Antigen Region||189-218 aa|
|Other Names||TIP41-like protein, Putative MAPK-activating protein PM10, Type 2A-interacting protein, TIP, TIPRL|
|Target/Specificity||This TIPRL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 189-218 amino acids from the C-terminal region of human TIPRL.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TIPRL Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be a allosteric regulator of serine/threonine- protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair.|
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Provided below are standard protocols that you may find useful for product applications.
TIPRL is an inhibitory regulator of protein phosphatase-2A (PP2A) (see PPP2CA; MIM 176915), PP4 (see PPP4C; MIM 602035), and PP6 (see PPP6C; MIM 612725) (McConnell et al., 2007 [PubMed 17384681]).
Ehret, G.B., et al. Eur. J. Hum. Genet. 17(12):1650-1657(2009)
Cheung, C.L., et al. Hum. Mol. Genet. 18(4):679-687(2009)
Rikova, K., et al. Cell 131(6):1190-1203(2007)
McConnell, J.L., et al. Oncogene 26(41):6021-6030(2007)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
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