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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   TIPRL Antibody (C-term)   

TIPRL Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - TIPRL Antibody (C-term) AP18140b
    TIPRL Antibody (C-term) (Cat. #AP18140b) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the TIPRL antibody detected the TIPRL protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O75663
Other Accession A2VCX1, Q8BH58, NP_001026970.1
Reactivity Human
Predicted Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 31444 Da
Antigen Region 189-218 aa
Additional Information
Gene ID 261726
Other Names TIP41-like protein, Putative MAPK-activating protein PM10, Type 2A-interacting protein, TIP, TIPRL
Target/Specificity This TIPRL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 189-218 amino acids from the C-terminal region of human TIPRL.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTIPRL Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function May be a allosteric regulator of serine/threonine- protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair.
Cellular Location Cytoplasm.
Research Areas
Citations (0)

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TIPRL is an inhibitory regulator of protein phosphatase-2A (PP2A) (see PPP2CA; MIM 176915), PP4 (see PPP4C; MIM 602035), and PP6 (see PPP6C; MIM 612725) (McConnell et al., 2007 [PubMed 17384681]).


Ehret, G.B., et al. Eur. J. Hum. Genet. 17(12):1650-1657(2009)
Cheung, C.L., et al. Hum. Mol. Genet. 18(4):679-687(2009)
Rikova, K., et al. Cell 131(6):1190-1203(2007)
McConnell, J.L., et al. Oncogene 26(41):6021-6030(2007)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :

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$ 295.00
$ 99.00
Cat# AP18140b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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