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AFF2 Antibody (Center)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
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| Catalog # | Size | Availability | Price | |
| AP18150c | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP18150c-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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AFF2 Antibody (Center) - Product info | |
| Application | WB
|
| Primary Accession | P51816 |
| Other Accession | NP_001162593.1 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 144771 Da |
AFF2 Antibody (Center) - Additional info | |
| Gene ID 2334 | |
| Other Names AFF2; FMR2; OX19; AF4/FMR2 family member 2; Fragile X E mental retardation syndrome protein; Fragile X mental retardation 2 protein; Protein Ox19 | |
| Target/Specificity This AFF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 885-912 amino acids from the Central region of human AFF2. | |
| Dilution WB~~1:100~500WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions AFF2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. | |
AFF2 Antibody (Center) - Protein Information | |
| Name AFF2 | |
| Synonyms FMR2, OX19 | |
| Function RNA-binding protein. Might be involved in alternative splicing regulation through an interaction with G-quartet RNA structure | |
| Cellular Location Nucleus speckle. Note=When splicing is inhibited, accumlates in enlarged speckles | |
| Tissue Location Brain (most abundant in hippocampus and amygdala), placenta and lung | |
AFF2 Antibody (Center) - Related products
AFF2 Antibody (Center) - Application data
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AFF2 Antibody (Center) (Cat. #AP18150c) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the AFF2 antibody detected the AFF2 protein (arrow).
AFF2 Antibody (Center) - Research Areas
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BACKGROUND
This gene encodes a putative transcriptional activator that is a member of the AF4FMR2 gene family. This gene is associated with the folate-sensitive fragile X E locus on chromosome X. A repeat polymorphism in the fragile X E locus results in silencing of this gene causing Fragile X E syndrome. Fragile X E syndrome is a form of nonsyndromic X-linked mental retardation. Alternate splicing results in multiple transcript variants.
REFERENCES
Bensaid, M., et al. Nucleic Acids Res. 37(4):1269-1279(2009) Brylawski, B.P., et al. Exp. Mol. Pathol. 82(2):190-196(2007) Sharma, D., et al. Genet. Epidemiol. 20(1):129-144(2001) Hillman, M.A., et al. J. Hum. Genet. 46(5):251-259(2001) Musumeci, S.A., et al. Clin Neurophysiol 111(9):1632-1636(2000)
