|Application ||WB, E|
|Calculated MW||130382 Da|
|Antigen Region||196-224 aa|
|Other Names||Filamin A-interacting protein 1-like, 130 kDa GPBP-interacting protein, 90 kDa GPBP-interacting protein, Protein down-regulated in ovarian cancer 1, DOC-1, FILIP1L, COL4A3BPIP, DOC1, GIP90|
|Target/Specificity||This FIL1L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 196-224 amino acids from the N-terminal region of human FIL1L.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FIL1L Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||COL4A3BPIP, DOC1, GIP90|
|Function||Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits melanoma growth When expressed in tumor- associated vasculature.|
|Cellular Location||Cytoplasm. Membrane. Nucleus|
|Tissue Location||Expressed in endothelial cells, colon and colon cancers. In the colon, expressed in the vasculature and muscularis mucosa. In colon cancer, strongly expressed in tumor stroma and the vasculature (at protein level). Expressed in ovarian epithelial cells. Down-regulated in ovarian cancer|
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Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits melanoma growth When expressed in tumor-associated vasculature.
Notaridou, M., et al. Int. J. Cancer (2010) In press :
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Quaye, L., et al. Hum. Mol. Genet. 18(10):1869-1878(2009)
Tandle, A.T., et al. Cytokine 30(6):347-358(2005)
Mok, S.C., et al. Gynecol. Oncol. 52(2):247-252(1994)
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