ENPP4 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q9Y6X5 |
Other Accession | A2VDP5, NP_055751.1 |
Reactivity | Human |
Predicted | Bovine |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 51641 Da |
Antigen Region | 171-200 aa |
Gene ID | 22875 |
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Other Names | Bis(5'-adenosyl)-triphosphatase ENPP4, AP3A hydrolase, AP3Aase, Ectonucleotide pyrophosphatase/phosphodiesterase family member 4, E-NPP 4, NPP-4, ENPP4, KIAA0879, NPP4 |
Target/Specificity | This ENPP4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 171-200 amino acids from the Central region of human ENPP4. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | ENPP4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ENPP4 |
---|---|
Synonyms | KIAA0879, NPP4 |
Function | Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors. |
Cellular Location | Cell membrane; Single-pass type I membrane protein |
Tissue Location | Expressed on the surface of vascular endothelia. |
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Provided below are standard protocols that you may find useful for product applications.
Background
ENPP4 belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
References
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Gijsbers, R., et al. J. Biol. Chem. 276(2):1361-1368(2001)
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