|Application ||WB, E|
|Other Accession||A2VDP5, NP_055751.1|
|Calculated MW||51641 Da|
|Antigen Region||171-200 aa|
|Other Names||Bis(5'-adenosyl)-triphosphatase ENPP4, AP3A hydrolase, AP3Aase, Ectonucleotide pyrophosphatase/phosphodiesterase family member 4, E-NPP 4, NPP-4, ENPP4, KIAA0879, NPP4|
|Target/Specificity||This ENPP4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 171-200 amino acids from the Central region of human ENPP4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ENPP4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed on the surface of vascular endothelia.|
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Provided below are standard protocols that you may find useful for product applications.
ENPP4 belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Gijsbers, R., et al. J. Biol. Chem. 276(2):1361-1368(2001)
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