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>   home   >   Products   >   Primary Antibodies   >   Developmental Biology   >   IZUM1 Antibody (N-term)   

IZUM1 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - IZUM1 Antibody  (N-term) AP18187a
    IZUM1 Antibody (N-term) (Cat. #AP18187a) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the IZUM1 antibody detected the IZUM1 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8IYV9
Other Accession NP_872381.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 38930 Da
Antigen Region 77-105 aa
Additional Information
Gene ID 284359
Other Names Izumo sperm-egg fusion protein 1, Oocyte binding/fusion factor, OBF, Sperm-specific protein izumo, IZUMO1
Target/Specificity This IZUM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 77-105 amino acids from the N-terminal region of human IZUM1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsIZUM1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Sperm-specific (at protein level). Detectable on sperm surface only after the acrosome reaction
Research Areas
Citations (0)

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The sperm-specific protein Izumo, named for a Japanese shrine dedicated to marriage, is essential for sperm-egg plasma membrane binding and fusion (Inoue et al., 2005 [PubMed 15759005]).


Ellerman, D.A., et al. Mol. Reprod. Dev. 76(12):1188-1199(2009)
Inoue, N., et al. Biochem. Biophys. Res. Commun. 377(3):910-914(2008)
Granados-Gonzalez, V., et al. Fertil. Steril. 90(4):1246-1248(2008)
Yatsenko, A.N., et al. Hum. Mol. Genet. 15(23):3411-3419(2006)
Inoue, N., et al. Nature 434(7030):234-238(2005)

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$ 295.00
$ 99.00
Cat# AP18187a
(40 western blots)
Availability: In Stock
Bulk Size
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