|Application ||WB, E|
|Calculated MW||60695 Da|
|Antigen Region||97-126 aa|
|Other Names||UDP-glucuronosyltransferase 2B7, UDPGT 2B7, 4-catechol estrogen-specific UDPGT, UDP-glucuronosyltransferase 2B9, UDPGT 2B9, UDPGTh-2, UGT2B7, UGTB2B9|
|Target/Specificity||This UGT2B7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 97-126 amino acids from the N-terminal region of human UGT2B7.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||UGT2B7 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.|
|Cellular Location||Microsome membrane; Single- pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
The UGTs (EC 22.214.171.124) serve a major role in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. UGT2B7 has unique specificity for 3,4-catechol estrogens and estriol, suggesting that it may play an important role in regulating the level and activity of these potent estrogen metabolites. Its subcellular location is the microsome.
Joy, M.S., et al. Eur. J. Clin. Pharmacol. 66(11):1119-1130(2010)
Canzian, F., et al. Hum. Mol. Genet. 19(19):3873-3884(2010)
Hu, M., et al. Pharmacogenet. Genomics 20(10):634-637(2010)
Woillard, J.B., et al. Br J Clin Pharmacol 69(6):675-683(2010)
Hwang, M.S., et al. Drug Metab. Pharmacokinet. 25(4):398-402(2010)
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