|Application ||WB, E|
|Other Accession||Q8VHX0, Q9JJV5, Q4R589, Q0VD05, NP_006530.1|
|Predicted||Bovine, Monkey, Mouse, Rat|
|Calculated MW||35549 Da|
|Antigen Region||28-56 aa|
|Other Names||Voltage-dependent calcium channel gamma-3 subunit, Neuronal voltage-gated calcium channel gamma-3 subunit, Transmembrane AMPAR regulatory protein gamma-3, TARP gamma-3, CACNG3|
|Target/Specificity||This CACNG3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 28-56 amino acids from the N-terminal region of human CACNG3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CACNG3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity).|
|Cellular Location||Membrane; Multi-pass membrane protein.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family. This gene is a susceptibility locus for childhood absence epilepsy.
Kato, A.S., et al. Trends Neurosci. 33(5):241-248(2010)
Sager, C., et al. Neuroscience 158(1):45-54(2009)
Everett, K.V., et al. Eur. J. Hum. Genet. 15(4):463-472(2007)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Chen, R.S., et al. Cell Biochem. Biophys. 47(2):178-186(2007)
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