|Application ||WB, E|
|Calculated MW||24003 Da|
|Antigen Region||175-202 aa|
|Other Names||Fibroblast growth factor 19, FGF-19, FGF19|
|Target/Specificity||This FGF19 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 175-202 amino acids from the C-terminal region of human FGF19.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FGF19 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4.|
|Tissue Location||Expressed in fetal brain, cartilage, retina, and adult gall bladder.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development.
Rao, A.S., et al. Gastroenterology 139(5):1549-1558(2010)
Turnbull, C., et al. Nat. Genet. 42(6):504-507(2010)
Schreuder, T.C., et al. Am. J. Physiol. Gastrointest. Liver Physiol. 298 (3), G440-G445 (2010) :
Reiche, M., et al. Horm. Metab. Res. 42(3):178-181(2010)
Wu, X., et al. J. Biol. Chem. 285(8):5165-5170(2010)
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