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SETD4 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9NVD3 |
| Other Accession | NP_001007260.1 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 50416 Da |
| Antigen Region | 14-41 aa |
| Gene ID | 54093 |
|---|---|
| Other Names | SET domain-containing protein 4, 211-, SETD4, C21orf18, C21orf27 |
| Target/Specificity | This SETD4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 14-41 amino acids from the N-terminal region of human SETD4. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SETD4 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SETD4 {ECO:0000303|PubMed:24738023, ECO:0000312|HGNC:HGNC:1258} |
|---|---|
| Function | Histone-lysine N-methyltransferase that acts as a regulator of cell proliferation, cell differentiation and inflammatory response (PubMed:31308046). Regulates the inflammatory response by mediating mono- and dimethylation of 'Lys-4' of histone H3 (H3K4me1 and H3K4me2, respectively), leading to activate the transcription of pro- inflammatory cytokines IL6 and TNF-alpha (By similarity). Also involved in the regulation of stem cell quiescence by catalyzing the trimethylation of 'Lys-20' of histone H4 (H4K20me3), thereby promoting heterochromatin formation (PubMed:31308046). Involved in proliferation, migration, paracrine and myogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) (By similarity). |
| Cellular Location | Cytoplasm, cytosol. Nucleus |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
C21orf18 contains 1 SET domain. The exact function is not known.
References
Hillman, R.T., et al. Genome Biol. 5 (2), R8 (2004) :
Reymond, A., et al. Genomics 78 (1-2), 46-54 (2001) :
Watanabe, K., et al. Genomics 52(1):95-100(1998)
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