|Application ||WB, E|
|Calculated MW||44741 Da|
|Antigen Region||7-33 aa|
|Other Names||Sphingosine-1-phosphate phosphatase 2, SPPase2, Spp2, hSPP2, 313-, Sphingosine-1-phosphatase 2, SGPP2|
|Target/Specificity||This SGPP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 7-33 amino acids from the N-terminal region of human SGPP2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SGPP2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Has specific phosphohydrolase activity towards sphingoid base 1-phosphates. Has high phosphohydrolase activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P) in vitro. May play a role in attenuating intracellular sphingosine 1-phosphate (S1P) signaling. May play a role in pro-inflammatory signaling.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
|Tissue Location||Expressed strongly in kidney and heart, followed by brain, colon, small intestine and lung. Not detected in skeletal muscle, thymus, spleen, liver, placenta, and peripheral blood leukocytes.|
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Provided below are standard protocols that you may find useful for product applications.
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that regulates diverse biologic processes. SGPP2 catalyzes the degradation of S1P (Ogawa et al., 2003 [PubMed 12411432]).
Mechtcheriakova, D., et al. Cell. Signal. 19(4):748-760(2007)
Ogawa, C., et al. J. Biol. Chem. 278(2):1268-1272(2003)
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