FRMD8 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q9BZ67 |
Other Accession | Q5U2R3, Q3UFK8, NP_114110.1 |
Reactivity | Human |
Predicted | Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 51218 Da |
Antigen Region | 74-100 aa |
Gene ID | 83786 |
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Other Names | FERM domain-containing protein 8, FRMD8 |
Target/Specificity | This FRMD8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 74-100 amino acids from the N-terminal region of human FRMD8. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | FRMD8 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | FRMD8 |
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Function | Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface (PubMed:29897333, PubMed:29897336). Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6 (PubMed:19572019). |
Cellular Location | Cytoplasm, cytosol. Cell membrane |
Tissue Location | Widely expressed, with high expression in heart and spleen. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The function of this protein remains unknown.
References
Barbe, L., et al. Mol. Cell Proteomics 7(3):499-508(2008)
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