|Application ||WB, E|
|Calculated MW||43955 Da|
|Antigen Region||78-104 aa|
|Other Names||Mitochondrial ribosome-associated GTPase 2, GTP-binding protein 5, Protein obg homolog 1, ObgH1, MTG2, GTPBP5, OBGH1|
|Target/Specificity||This GTPBP5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 78-104 amino acids from the N-terminal region of human GTPBP5.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GTPBP5 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays GTPase activity. Involved in the ribosome maturation process.|
|Cellular Location||Mitochondrion. Mitochondrion inner membrane; Peripheral membrane protein; Matrix side|
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Provided below are standard protocols that you may find useful for product applications.
Small G proteins, such as GTPBP5, act as molecular switches that play crucial roles in the regulation of fundamental cellular processes such as protein synthesis, nuclear transport, membrane trafficking, and signal transduction (Hirano et al., 2006 [PubMed 17054726]).
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Hirano, Y., et al. Genes Cells 11(11):1295-1304(2006)
Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006)
Deloukas, P., et al. Nature 414(6866):865-871(2001)
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