MTF2 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q9Y483 |
Other Accession | Q02395, NP_001157863.1 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 67090 Da |
Antigen Region | 289-317 aa |
Gene ID | 22823 |
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Other Names | Metal-response element-binding transcription factor 2, Metal regulatory transcription factor 2, Metal-response element DNA-binding protein M96, Polycomb-like protein 2, hPCl2, MTF2, PCL2 |
Target/Specificity | This MTF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 289-317 amino acids from the Central region of human MTF2. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | MTF2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | MTF2 |
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Synonyms | PCL2 |
Function | Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity (PubMed:23142980, PubMed:23228662, PubMed:31959557). Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation (By similarity). Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells (By similarity). Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex (By similarity). In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally (By similarity). Binds to the metal- regulating-element (MRE) of MT1A gene promoter (By similarity). |
Cellular Location | Nucleus. Note=Localizes to chromatin as part of the PRC2 complex |
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Provided below are standard protocols that you may find useful for product applications.
Background
MTF2 binds to the metal-regulating-element (MRE) of metallothionein-1A gene promoter. Binding is zinc-dependent (By similarity).
References
Wang, S., et al. Gene 343(1):69-78(2004)
Colland, F., et al. Genome Res. 14(7):1324-1332(2004)
Inouye, C., et al. DNA Cell Biol. 13(7):731-742(1994)
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