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ZFP57 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9NU63 |
| Other Accession | NP_001103279.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 51919 Da |
| Antigen Region | 269-296 aa |
| Gene ID | 346171 |
|---|---|
| Other Names | Zinc finger protein 57 homolog, Zfp-57, Zinc finger protein 698, ZFP57, C6orf40, ZNF698 |
| Target/Specificity | This ZFP57 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 269-296 amino acids from the Central region of human ZFP57. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ZFP57 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ZFP57 (HGNC:18791) |
|---|---|
| Synonyms | C6orf40, ZNF698 |
| Function | Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions (ICRs) (PubMed:18622393, PubMed:30602440). Acts together with ZNF445, but ZNF445 seems to be the major factor in human early embryonic imprinting maintenance. In contrast, in mice, ZFP57 plays the predominant role in imprinting maintenance (PubMed:30602440). Required for the establishment of maternal methylation imprints at SNRPN locus. Acts as a transcriptional repressor in Schwann cells. Binds to a 5'-TGCCGC-3' consensus sequence and recognizes the methylated CpG within this element (By similarity). |
| Cellular Location | Nucleus. Note=Binds various differentially methylated regions (DMR) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a zinc finger protein containing a KRAB domain. Studies in mouse suggest that this protein may function as a transcriptional repressor. Mutations in this gene have been associated with transient neonatal diabetes mellitus type 1 (TNDM1).
References
Spengler, S., et al. Eur J Med Genet 52(6):415-416(2009)
Barcellos, L.F., et al. PLoS Genet. 5 (10), E1000696 (2009) :
Tse, K.P., et al. Am. J. Hum. Genet. 85(2):194-203(2009)
Li, X., et al. Dev. Cell 15(4):547-557(2008)
Mackay, D.J., et al. Nat. Genet. 40(8):949-951(2008)
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