|Application ||WB, E|
|Calculated MW||51919 Da|
|Antigen Region||269-296 aa|
|Other Names||Zinc finger protein 57 homolog, Zfp-57, Zinc finger protein 698, ZFP57, C6orf40, ZNF698|
|Target/Specificity||This ZFP57 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 269-296 amino acids from the Central region of human ZFP57.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ZFP57 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds to a 5'-TGCCGC-3' consensus sequence and recognizes the methylated CpG within this element (By similarity). Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions. Required for the establishment of maternal methylation imprints at SNRPN locus. Acts as a transcriptional repressor in Schwann cells.|
|Cellular Location||Nucleus. Note=Binds various differentially methylated regions (DMR), including the SNRPN DMR|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a zinc finger protein containing a KRAB domain. Studies in mouse suggest that this protein may function as a transcriptional repressor. Mutations in this gene have been associated with transient neonatal diabetes mellitus type 1 (TNDM1).
Spengler, S., et al. Eur J Med Genet 52(6):415-416(2009)
Barcellos, L.F., et al. PLoS Genet. 5 (10), E1000696 (2009) :
Tse, K.P., et al. Am. J. Hum. Genet. 85(2):194-203(2009)
Li, X., et al. Dev. Cell 15(4):547-557(2008)
Mackay, D.J., et al. Nat. Genet. 40(8):949-951(2008)
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