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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PLEKHA8 Antibody (C-term)   

PLEKHA8 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - PLEKHA8 Antibody (C-term) AP18305b
    PLEKHA8 Antibody (C-term) (Cat. #AP18305b) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the PLEKHA8 antibody detected the PLEKHA8 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q96JA3
Other Accession O95397, NP_116028.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 58261 Da
Antigen Region 456-482 aa
Additional Information
Gene ID 84725
Other Names Pleckstrin homology domain-containing family A member 8, PH domain-containing family A member 8, Phosphatidylinositol-four-phosphate adapter protein 2, FAPP-2, Phosphoinositol 4-phosphate adapter protein 2, hFAPP2, Serologically defined breast cancer antigen NY-BR-86, PLEKHA8, FAPP2
Target/Specificity This PLEKHA8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 456-482 amino acids from the C-terminal region of human PLEKHA8.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPLEKHA8 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PLEKHA8
Synonyms FAPP2
Function Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans- Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation.
Cellular Location Golgi apparatus, trans-Golgi network membrane. Membrane; Peripheral membrane protein. Note=Binds through its PH domain to PtdIns(4)P and ARF1, and subsequently localizes to TGN exit sites.
Tissue Location Expressed in kidney cell lines.
Research Areas
Citations (0)

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Background

PLEKHA8 is involved in TGN-to-plasma membrane transport and in the formation of post-Golgi constitutive carriers. May play a role in ensuring the coordination of the budding and the fission reactions.

References

Tsao, D.A., et al. DNA Cell Biol. 29(6):285-293(2010)
Cao, X., et al. Proc. Natl. Acad. Sci. U.S.A. 106(50):21121-21125(2009)
Tritz, R., et al. Biochem. Biophys. Res. Commun. 383(2):167-171(2009)
Yamaji, T., et al. IUBMB Life 60(8):511-518(2008)
D'Angelo, G., et al. Nature 449(7158):62-67(2007)

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$ 295.00
$ 99.00
Cat# AP18305b
Size:
Quantity:
(40 western blots)
Availability: In Stock
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