GSX2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q9BZM3 |
Other Accession | NP_573574.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 32031 Da |
Antigen Region | 243-269 aa |
Gene ID | 170825 |
---|---|
Other Names | GS homeobox 2, Homeobox protein GSH-2, GSX2, GSH2 |
Target/Specificity | This GSX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 243-269 amino acids from the C-terminal region of human GSX2. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | GSX2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | GSX2 |
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Synonyms | GSH2 |
Function | Transcription factor that binds 5'-CNAATTAG-3' DNA sequence and regulates the expression of numerous genes including genes important for brain development (PubMed:31412107). During telencephalic development, causes ventralization of pallial progenitors and, depending on the developmental stage, specifies different neuronal fates. At early stages, necessary and sufficient to correctly specify the ventral lateral ganglionic eminence (LGE) and its major derivatives, the striatal projection neurons. At later stages, may specify LGE progenitors toward dorsal LGE fates, including olfactory bulb interneurons (By similarity). |
Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:31412107}. Cytoplasm |
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Provided below are standard protocols that you may find useful for product applications.
Background
GSX2 is probable transcription factor that binds to the DNA sequence 5'-CNAATTAG-3' (By similarity).
References
Waclaw, R.R., et al. Neuron 63(4):451-465(2009)
Wu, C., et al. Proteomics 7(11):1775-1785(2007)
Dauwerse, J.G., et al. J. Med. Genet. 39(9):686-688(2002)
Cools, J., et al. Blood 99(5):1776-1784(2002)
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