TXNDC5 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q8NBS9 |
Other Accession | Q91W90, NP_001139021.1 |
Reactivity | Human |
Predicted | Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 47629 Da |
Antigen Region | 128-155 aa |
Gene ID | 81567 |
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Other Names | Thioredoxin domain-containing protein 5, Endoplasmic reticulum resident protein 46, ER protein 46, ERp46, Thioredoxin-like protein p46, TXNDC5, TLP46 |
Target/Specificity | This TXNDC5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 128-155 amino acids from the Central region of human TXNDC5. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | TXNDC5 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TXNDC5 (HGNC:21073) |
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Synonyms | TLP46 |
Function | Protein disulfide isomerase of the endoplasmic reticulum lumen involved in the formation of disulfide bonds in proteins. Can reduce insulin disulfide bonds. |
Cellular Location | Endoplasmic reticulum lumen {ECO:0000250|UniProtKB:Q91W90, ECO:0000255|PROSITE-ProRule:PRU10138} |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein-disulfide isomerase. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream MUTED (muted homolog) gene.
References
Zhang, L., et al. J. Cancer Res. Clin. Oncol. 136(10):1497-1505(2010)
Jeong, K.H., et al. Br. J. Dermatol. 162(4):759-764(2010)
Charlton, H.K., et al. Biochem. Biophys. Res. Commun. 392(2):234-239(2010)
So, H.C., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (1), 103-113 (2010) :
Jessop, C.E., et al. J. Cell. Sci. 122 (PT 23), 4287-4295 (2009) :
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