|Application ||WB, E|
|Calculated MW||37731 Da|
|Antigen Region||49-77 aa|
|Other Names||Gonadotropin-releasing hormone receptor, GnRH receptor, GnRH-R, GNRHR, GRHR|
|Target/Specificity||This GNRHR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 49-77 amino acids from the N-terminal region of human GNRHR.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GNRHR Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle- stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol- calcium second messenger system. Isoform 2 may act as an inhibitor of GnRH-R signaling.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Pituitary, ovary, testis, breast and prostate but not in liver and spleen|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene.
Canzian, F., et al. Hum. Mol. Genet. 19(19):3873-3884(2010)
Armstrong, S.P., et al. J. Biol. Chem. 285(32):24360-24371(2010)
Lee, G., et al. Cancer Immunol. Immunother. 59(7):1011-1019(2010)
Re, M., et al. PLoS ONE 5 (7), E11489 (2010) :
Armstrong, S.P., et al. J. Biol. Chem. 284(51):35746-35757(2009)
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