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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   LMNA Antibody (Center)   

LMNA Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - LMNA Antibody (Center) AP18319c
    LMNA Antibody (Center) (Cat. #AP18319c) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the LMNA Antibody detected the LMNA protein (arrow).
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Product Information
ApplicationWB, E
Primary AccessionP02545
Other AccessionNP_733821.1
ReactivityHuman
HostRabbit
ClonalityPolyclonal
IsotypeRabbit Ig
Calculated MW74139 Da
Antigen Region401-427 aa
Additional Information
Gene ID4000
Other NamesPrelamin-A/C, Lamin-A/C, 70 kDa lamin, Renal carcinoma antigen NY-REN-32, LMNA, LMN1
Target/SpecificityThis LMNA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 401-427 amino acids from the Central region of human LMNA.
DilutionWB~~1:1000
FormatPurified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Protein Information
NameLMNA
SynonymsLMN1
Function Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation. Required for osteoblastogenesis and bone formation. Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone.
Cellular LocationNucleus. Nucleus envelope. Nucleus lamina. Nucleus, nucleoplasm. Note=Farnesylation of prelamin-A/C facilitates nuclear envelope targeting and subsequent cleaveage by ZMPSTE24/FACE1 to remove the farnesyl group produces mature lamin- A/C, which can then be inserted into the nuclear lamina. EMD is required for proper localization of non-farnesylated prelamin-A/C
Tissue LocationIn the arteries, prelamin-A/C accumulation is not observed in young healthy vessels but is prevalent in medial vascular smooth muscle cells (VSMCs) from aged individuals and in atherosclerotic lesions, where it often colocalizes with senescent and degenerate VSMCs. Prelamin-A/C expression increases with age and disease. In normal aging, the accumulation of prelamin-A/C is caused in part by the down-regulation of ZMPSTE24/FACE1 in response to oxidative stress.
Research Areas
Citations (0)

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Background

The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Through alternate splicing, this gene encodes three type A lamin isoforms. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Wegner, L., et al. J. Clin. Endocrinol. Metab. 95(8):3884-3892(2010)
Drac, H., et al. Neurol. Neurochir. Pol. 44(3):291-296(2010)
Liu, Q., et al. PLoS ONE 5 (5), E10874 (2010) :
Chaturvedi, P., et al. PLoS ONE 5 (5), E10620 (2010) :

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$ 265.00
$ 95.00
Cat# AP18319c
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(40 western blots)
Availability: In Stock
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