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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   CCNF Antibody (Center)   

CCNF Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - CCNF  Antibody (Center) AP18322c
    CCNF Antibody (Center) (Cat. #AP18322c) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the CCNF Antibody detected the CCNF protein (arrow).
  • WB - CCNF  Antibody (Center) AP18322c
    CCNF Antibody (Center) (Cat. #AP18322c) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the CCNF Antibody detected the CCNF protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P41002
Other Accession NP_001752.2
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 87640 Da
Antigen Region 496-524 aa
Additional Information
Gene ID 899
Other Names Cyclin-F, F-box only protein 1, CCNF, FBX1, FBXO1
Target/Specificity This CCNF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 496-524 amino acids from the Central region of human CCNF.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCCNF Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms FBX1, FBXO1
Function Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication.
Cellular Location Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Note=Localization in the centrosome is rare in S phase cells and increases in G2 cells, Localizes on both the mother and daughter centrioles. Localization to centrosomes is not dependent on CP110 Also localizes to the nucleus
Tissue Location Widely expressed.
Research Areas
Citations (0)

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This gene encodes a member of the cyclin family. Cyclins are important regulators of cell cycle transitions through their ability to bind and activate cyclin-dependent protein kinases. This member also belongs to the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it was one of the first proteins in which the F-box motif was identified.


D'Angiolella, V., et al. Nature 466(7302):138-142(2010)
Fung, T.K., et al. J. Biol. Chem. 277(38):35140-35149(2002)
Kong, M., et al. EMBO J. 19(6):1378-1388(2000)
Bai, C., et al. Cell 86(2):263-274(1996)
Bai, C., et al. EMBO J. 13(24):6087-6098(1994)

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$ 295.00
$ 99.00
Cat# AP18322c
(40 western blots)
Availability: In Stock
Bulk Size
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