|Application ||WB, E|
|Other Accession||Q8BGT0, NP_054747.2|
|Calculated MW||37257 Da|
|Antigen Region||292-321 aa|
|Other Names||Osteopetrosis-associated transmembrane protein 1, Chloride channel 7 beta subunit, OSTM1, GL|
|Target/Specificity||This OSTM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 292-321 amino acids from the C-terminal region of human OSTM1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||OSTM1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for osteoclast and melanocyte maturation and function.|
|Cellular Location||Lysosome membrane; Single-pass type I membrane protein. Note=Requires CLCN7 to travel to lysosomes|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein that may be involved in the degradation of G proteins via the ubiquitin-dependent proteasome pathway. The encoded protein binds to members of subfamily A of the regulator of the G-protein signaling (RGS) family through an N-terminal leucine-rich region. This protein also has a central RING finger-like domain and E3 ubiquitin ligase activity. This protein is highly conserved from flies to humans. Defects in this gene may cause the autosomal recessive, infantile malignant form of osteopetrosis.
Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)
Mazzolari, E., et al. Am. J. Hematol. 84(8):473-479(2009)
Vieira, A.R., et al. Genet. Med. 10(9):668-674(2008)
Feigin, M.E., et al. Cell. Signal. 20(5):949-957(2008)
Maranda, B., et al. J. Bone Miner. Res. 23(2):296-300(2008)
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