|Application ||WB, E|
|Calculated MW||114078 Da|
|Antigen Region||453-482 aa|
|Other Names||Anoctamin-1, Discovered on gastrointestinal stromal tumors protein 1, Oral cancer overexpressed protein 2, Transmembrane protein 16A, Tumor-amplified and overexpressed sequence 2, ANO1, DOG1, ORAOV2, TAOS2, TMEM16A|
|Target/Specificity||This ANO1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 453-482 amino acids from the Central region of human ANO1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ANO1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||DOG1, ORAOV2, TAOS2, TMEM16A|
|Function||Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development.|
|Cellular Location||Cell membrane; Multi- pass membrane protein. Cytoplasm. Note=Cytoplasmic localization seen in neoplastic cells of head and neck squamous cell carcinoma (HNSCC) tumors.|
|Tissue Location||Broadly expressed with higher levels in liver, skeletal muscle and gastrointestinal muscles|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
ANO1 acts as a calcium-activated chloride channel. Required for normal tracheal development (By similarity).
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Barro-Soria, R., et al. Pflugers Arch. 459(3):485-497(2010)
Hosgood, H.D. III, et al. Occup Environ Med 66(12):848-853(2009)
Ferrera, L., et al. J. Biol. Chem. 284(48):33360-33368(2009)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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