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NOX3 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9HBY0 |
| Other Accession | NP_056533.1 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 64935 Da |
| Antigen Region | 73-102 aa |
| Gene ID | 50508 |
|---|---|
| Other Names | NADPH oxidase 3, 163-, Mitogenic oxidase 2, MOX-2, gp91phox homolog 3, GP91-3, NOX3, MOX2 |
| Target/Specificity | This NOX3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 73-102 amino acids from the N-terminal region of human NOX3. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | NOX3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NOX3 |
|---|---|
| Synonyms | MOX2 |
| Function | NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor, upon formation of a complex with CYBA/p22phox (PubMed:15181005, PubMed:15824103). Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity (By similarity). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q672J9}; Multi-pass membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the NOX family of NADPH oxidases. These enzymes have the capacity to generate superoxide and other reactive oxygen species (ROS) and transport electrons across the plasma membrane. The ROS generated by family members have been implicated in numerous biological functions including host defense, posttranlational processing of proteins, cellular signaling, regulation of gene expression, and cell differentiation. The protein encoded by this gene is expressed predominantly in the inner ear and is involved in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Gao, D., et al. J. Biol. Chem. 285(39):29965-29973(2010)
Li, L., et al. FEBS Lett. 584(5):995-1000(2010)
Segat, L., et al. Vaccine 28(10):2201-2206(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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