METTL6 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q8TCB7 |
Other Accession | NP_689609.2 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 33251 Da |
Antigen Region | 168-195 aa |
Gene ID | 131965 |
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Other Names | Methyltransferase-like protein 6, 211-, METTL6 |
Target/Specificity | This METTL6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 168-195 amino acids from the Central region of human METTL6. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | METTL6 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | METTL6 {ECO:0000303|PubMed:32923617, ECO:0000312|HGNC:HGNC:28343} |
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Function | S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Ser), including tRNA(Ser)(UGA) and tRNA(Ser)(GCU) (PubMed:32923617, PubMed:34922197, PubMed:34268557, PubMed:34862464). Interaction with SARS1/SerRS is required for N(3)- methylcytidine methylation (PubMed:34268557). |
Cellular Location | Cytoplasm. Nucleus |
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Provided below are standard protocols that you may find useful for product applications.
Background
Probable methyltransferase (By similarity).
References
McArdle, P.F., et al. Arthritis Rheum. 58(9):2874-2881(2008)
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