|Application ||WB, E|
|Calculated MW||30855 Da|
|Antigen Region||222-249 aa|
|Other Names||Non-structural maintenance of chromosomes element 1 homolog, Non-SMC element 1 homolog, 632-, NSMCE1|
|Target/Specificity||This NSMCE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 222-249 amino acids from the C-terminal region of human NSMCE1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NSMCE1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT- associated PML bodies (APBs). Has in vitro ubiquitin ligase activity in presence of NSMCE3. Is involved in positive regulation of response to DNA damage stimulus.|
|Cellular Location||Nucleus. Chromosome, telomere|
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Provided below are standard protocols that you may find useful for product applications.
Probable component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks (By similarity).
Fujioka, Y., et al. J. Biol. Chem. 277(24):21585-21591(2002)
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