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ZNRF4 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q8WWF5 |
| Other Accession | Q4R6Y5, NP_859061.3 |
| Reactivity | Human |
| Predicted | Monkey |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 46958 Da |
| Antigen Region | 111-138 aa |
| Gene ID | 148066 |
|---|---|
| Other Names | Zinc/RING finger protein 4, RING finger protein 204, ZNRF4, RNF204 |
| Target/Specificity | This ZNRF4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 111-138 amino acids from the N-terminal region of human ZNRF4. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ZNRF4 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ZNRF4 (HGNC:17726) |
|---|---|
| Function | E3 ubiquitin-protein ligase that acts as a negative regulator of NOD2 signaling by mediating ubiquitination and degradation of RIPK2 (PubMed:28656966). Also catalyzes ubiquitination and proteasomal degradation of CANX within the endoplasmic reticulum (PubMed:21205830). Could have a role in spermatogenesis (By similarity). |
| Cellular Location | Endoplasmic reticulum membrane; Single-pass type I membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
ZNRF4 contains 1 PA (protease associated) domain and 1 RING-type zinc finger.
References
Grimwood, J., et al. Nature 428(6982):529-535(2004)
Fujii, T., et al. Genomics 57(1):94-101(1999)
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