|Application ||WB, E|
|Other Accession||Q9GZY0, NP_116564.2|
|Calculated MW||45628 Da|
|Antigen Region||53-80 aa|
|Other Names||Nuclear RNA export factor 5, TAP-like protein 1, TAPL-1, NXF5, TAPL1|
|Target/Specificity||This NXF5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 53-80 amino acids from the N-terminal region of human NXF5.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NXF5 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Could be involved in the export of mRNA from the nucleus to the cytoplasm. Could also have a role in polarized cytoplasmic transport and localization of mRNA in neurons.|
|Cellular Location||Cytoplasm. Nucleus. Note=Mainly localized in the cytoplasm of cells and more particularly in the cell body and neurites of hippocampal neurons. Although nuclear localization is also observed. Not detected at nuclear rim|
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Provided below are standard protocols that you may find useful for product applications.
This gene is one member of a family of nuclear RNA export factor genes. The encoded protein can bind RNA, and is implicated in mRNA nuclear export. However, this protein has lost several C-terminal protein domains found in other family members that are required for export activity, and may be an evolving pseudogene. Alternatively spliced transcript variants have been described, but most are candidates for nonsense-mediated decay (NMD) and may not express proteins in vivo.
Tarpey, P.S., et al. Nat. Genet. 41(5):535-543(2009)
Hillman, R.T., et al. Genome Biol. 5 (2), R8 (2004) :
Frints, S.G., et al. Am. J. Med. Genet. A 119A (3), 367-374 (2003) :
Jun, L., et al. Curr. Biol. 11(18):1381-1391(2001)
Herold, A., et al. Mol. Cell. Biol. 20(23):8996-9008(2000)
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