|Application ||WB, E|
|Calculated MW||83970 Da|
|Antigen Region||669-695 aa|
|Other Names||Oxysterol-binding protein-related protein 10, ORP-10, OSBP-related protein 10, OSBPL10, ORP10, OSBP9|
|Target/Specificity||This OSBPL10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 669-695 amino acids from the C-terminal region of human OSBPL10.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||OSBPL10 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Probable lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P (PubMed:23934110) (Probable). Plays a role in negative regulation of lipid biosynthesis (PubMed:19554302). Negatively regulates APOB secretion from hepatocytes (PubMed:19554302, PubMed:22906437). Binds cholesterol and acidic phospholipids (PubMed:22906437). Also binds 25-hydroxycholesterol (PubMed:17428193). Binds phosphatidylserine (PubMed:23934110).|
|Cellular Location||Cytoplasm, cytoskeleton Note=Associates with microtubules.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Multiple transcript variants encoding different isoforms have been found for this gene.
Koriyama, H., et al. J. Atheroscler. Thromb. 17(10):1054-1062(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Koriyama, H., et al. Hypertens. Res. 33(5):511-514(2010)
Perttila, J., et al. J. Mol. Med. 87(8):825-835(2009)
Ma, J., et al. Atherosclerosis 191(1):63-72(2007)
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