|Application ||WB, E|
|Other Accession||Q01717, NP_003292.1|
|Calculated MW||45085 Da|
|Antigen Region||209-238 aa|
|Other Names||Thyrotropin-releasing hormone receptor, TRH-R, Thyroliberin receptor, TRHR|
|Target/Specificity||This TRHR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 209-238 amino acids from the Central region of human TRHR.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TRHR Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for thyrotropin-releasing hormone. This receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
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Provided below are standard protocols that you may find useful for product applications.
Thyrotropin-releasing hormone (TRH; MIM 275120), a small neuropeptide, is widely distributed throughout the central and peripheral nervous system as well as in extraneural tissues. The peptide is synthesized in the hypothalamus and transported by the portal vascular system to the anterior pituitary where it acts on thyrotropic and lactotropic cells to promote secretion of TSH and prolactin, respectively. Thyrotropin-releasing hormone receptor is a G protein-coupled receptor that activates the inositol phospholipid-calcium-protein kinase C transduction pathway upon the binding of TRH. The TRHR gene is expressed in the thyrotrope cells of the anterior pituitary.
Gehret, A.U., et al. Biochem. J. 428(2):235-245(2010)
Gehret, A.U., et al. Mol. Pharmacol. 77(2):288-297(2010)
Zhu, C.C., et al. J. Biol. Chem. 277(31):28228-28237(2002)
Matre, V., et al. J. Neurochem. 72(1):40-50(1999)
Iwasaki, T., et al. J. Biol. Chem. 271(36):22183-22188(1996)
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