|Application ||WB, E|
|Calculated MW||98141 Da|
|Antigen Region||20-47 aa|
|Other Names||Scm-like with four MBT domains protein 1, hSFMBT, Renal ubiquitous protein 1, SFMBT1, RU1|
|Target/Specificity||This SFMBT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 20-47 amino acids from the N-terminal region of human SFMBT1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SFMBT1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Histone-binding protein, which is part of various corepressor complexes. Mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. Plays a role during myogenesis: required for the maintenance of undifferentiated states of myogenic progenitor cells via interaction with MYOD1. Interaction with MYOD1 leads to the recruitment of associated corepressors and silencing of MYOD1 target genes. Part of the SLC complex in germ cells, where it may play a role during spermatogenesis.|
|Tissue Location||Expressed in all cell lines and normal tissues tested, including the thymus.|
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Provided below are standard protocols that you may find useful for product applications.
This gene shares high similarity with the Drosophila Scm (sex comb on midleg) gene. It encodes a protein which contains four malignant brain tumor repeat (mbt) domains and may be involved in antigen recognition. Several alternative splice variants that encode the same protein have been characterized. [provided by RefSeq].
Wu, S., et al. FEBS Lett. 581(17):3289-3296(2007)
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