|Application ||WB, E|
|Other Accession||Q8BHG9, NP_001008391.1|
|Calculated MW||18820 Da|
|Antigen Region||126-152 aa|
|Other Names||CGG triplet repeat-binding protein 1, CGG-binding protein 1, 20 kDa CGG-binding protein, p20-CGGBP DNA-binding protein, CGGBP1, CGGBP|
|Target/Specificity||This CGGBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 126-152 amino acids from the C-terminal region of human CGGBP1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CGGBP1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds to nonmethylated 5'-d(CGG)(n)-3' trinucleotide repeats in the FMR1 promoter. May play a role in regulating FMR1 promoter.|
|Tissue Location||Ubiquitous. Highly expressed in placenta, thymus, lymph nodes, cerebellum and cerebral cortex. Low expression in other regions of the brain|
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Provided below are standard protocols that you may find useful for product applications.
CGGBP1 influences expression of the FMR1 gene (MIM 309550), which is associated with the fragile X mental retardation syndrome (MIM 300624), by specifically interacting with the 5-prime (CGG)n-3-prime repeat in its 5-prime UTR.
Gulyi, P.V., et al. Tsitologiia 51(12):1005-1012(2009)
Arrieta, I., et al. Hum. Biol. 80(6):593-600(2008)
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
Naumann, F., et al. Genomics 83(1):106-118(2004)
Chen, L.S., et al. Hum. Mol. Genet. 12(23):3067-3074(2003)
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