|Application ||WB, E|
|Calculated MW||68114 Da|
|Antigen Region||502-528 aa|
|Other Names||Guanylate-binding protein 3, GTP-binding protein 3, GBP-3, Guanine nucleotide-binding protein 3, GBP3|
|Target/Specificity||This GBP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 502-528 amino acids from the C-terminal region of human GBP3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GBP3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Exhibits antiviral activity against influenza virus.|
|Cellular Location||Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus membrane Note=Heterodimers with GBP1, GBP2 and GBP5 localize in the compartment of the prenylated GBPs: with GBP1 in a vesicle-like compartment, with GBP2, around the nucleus and with GBP-5, at the Golgi aparatus.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the guanylate-binding protein (GBP) family. GBPs specifically bind guanine nucleotides (GMP, GDP, and GTP) and contain two of the three consensus motifs found in typical GTP-binding proteins. The encoded protein interacts with a member of the germinal center kinase family.
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Luan, Z., et al. FEBS Lett. 530 (1-3), 233-238 (2002) :
Strehlow, I., et al. Gene 144(2):295-299(1994)
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